KMID : 0869220150190020072
|
|
Journal of Korean Geriatric Psychiatry 2015 Volume.19 No. 2 p.72 ~ p.78
|
|
Extrapyramidal Signs and Impairment of Cognitive Subdomains in Mild Cognitive Impairment : A Clinical Research Center for Dementia of South Korea (CREDOS) Study
|
|
Park Jin-Hong
Myung Woo-Jae Choi Jun-Bae Kim Sang-Ha Kang Hyo-Shin Na Duk-Lyul Kim Seong-Yoon Lee Jae-Hong Han Seol-Heui Choi Seong-Hye Kim Sang-Yun Kim Doh-Kwan
|
|
Abstract
|
|
|
Objective£ºThis study investigated the association between extrapyramidal signs (EPS) and five cognitive sub-domains in a large number of patients with mild cognitive impairment (MCI).
Methods£ºOur analyses considered 1,943 patients with MCI drawn from the nationwide Clinical Research of Dementia of South Korea study. EPS were defined as presence in patients with at least 1 of 11 operationally specified features. We assessed five cognitive sub-domains : attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuropsychological Screening Battery-Dementia version. The associations of EPS with each cognitive sub-domain were analyzed with a multiple linear regression model after controlling for confounding factors : sex, age, education years, diabetes, hypertension, severity of global function, depressive symptoms, and white matter hyperintensities (WMH).
Results£º138 MCI patients (7.1%) had EPS. This group had more global cognitive deterioration and severe WMH. MCI patients with EPS showed lower performance compared to those without EPS in 3 cognitive sub-domains: attention (p=0.05), visuospatial function (p=0.02), and frontal/executive function (p<0.0001). The language sub-domain and the memory sub-domain did not differ between the EPS positive and the EPS negative groups.
Conclusion£ºEPS in MCI are associated with greater cognitive impairment in specific functional sub-domains rather than with global greater cognitive deterioration.
|
|
KEYWORD
|
|
Mild cognitive impairment, Extrapyramidal signs, Cognition
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|